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COMPETITIVE CALL

 

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Information about DoReMi competitive calls

The substantial scientific challenges related to the low dose risk research require a multidisciplinary approach and new competencies and capacities. Therefore, a large portion of DoReMi Flexibility budget has been reserved to organizes competitive calls for proposals to identify new partners to answer to these emerging needs for integrated research.

The first competitive call was organized in 2010 and as a result, ten new beneficiaries joined the consortium. The second competitive call was organized in 2012, and ten more new beneficiaries joined the consortium. The third competitive call organized in 2013 was directed to the new members states of the European Union, and four new beneficiaries joined the consortium - which now counts with altogether 36 organisations from Europe and Japan.

The list of DoReMi partners is available here.

 

The 3rd competitive call process has been completed and four new organizations have joined DoReMi from July 2014 onwards. »» More information about new partners »»


3rd Competitive call for additional project partner

The European Network of Excellence DoReMi addresses the health risks of low doses of ionising radiation such as those that are encountered in the environment, occupationally and in the course of medical diagnostic procedures.

Call identifier: DoReMi-2013
Publication Date: 23 October 2013
Budget: € 200 000 (EC contribution)
Deadline: The call closed on 11 December 2013, 17h00 (Brussels time)

DoReMi-2013 Call announcement is available below.
  »
Printable version as well as other call-related documentation are available at the bottom of this page:

ANNOUNCEMENT OF A COMPETITIVE CALL FOR ADDITIONAL PROJECT PARTNERS
The following project currently active in the Seventh Framework programme of the European Atomic Energy Community for research, technological development and demonstration activities contributing to the creation of the European research area and to innovation (2007-2011) requires the participation of new project partners to carry out work within the project. Please note that the Seventh Framework Programme offers part-funding not full-funding of research activities.

Project grant agreement number: 249689
Project acronym: DoReMi
Project full name: Low Dose Research towards Multidisciplinary Integration
Instrument type: Network of excellence

The call is directed to organisations from EU member states that have joined the community from year 2004 onwards: the Czech Republic, Estonia, Hungary, Latvia, Lithuania, Poland, Slovakia, Slovenia, Malta, Cyprus, Bulgaria, Romania and Croatia. Legal entities from these countries only may participate in this call.

Brief summary of work requested:
To address the health risks of low doses of ionising radiation such as those that are encountered in the environment, occupationally and in the course of medical diagnostic procedures (these are described further in the High Level and Expert Group Report on Low Dose Risk (www.hleg.de) and the DoReMi Transitional Research Agenda (first version published in September 2010), and TRA Statement version 3 (published in October 2013), the DoReMi consortium is seeking new expertise, infrastructures and platforms for analyses related to the work packages described below. The DoReMi defines low doses as those of 100 mGy or less and medium doses as 0.1 Gy - 1 Gy for low LET radiations. Low and medium dose rates are defined as 0.1 Gy/h or less for low LET radiations. For high-LET radiations, dose and dose-rates of interest are lower, e.g. for alpha radiation by an order of magnitude.

The main goal of the third DoReMi competitive call is to integrate the successful organisations from the above-mentioned member states to DoReMi's existing work packages, to strengthen the ongoing lines of research.


Work package 4 focuses on improving knowledge of and access to research infrastructures for DoReMi partners. These infrastructure resources include a vast array of irradiation facilities, databases and biobanks, epidemiological cohorts and analytical platforms. Applications are encouraged which take advantage of the available infrastructure resources while addressing the needs of work packages 5, 6, or 7. General information on the available infrastructure resources can be found on the DoReMi website. New complementary infrastructures can be proposed as well as proposals for the use of existing DoReMi infrastructures.


Work package 5 concerns the shape of the dose-response for radiation-induced cancer. A range of studies are undertaken and organised into tasks. The research effort aims to develop a better understanding of dose-response relationships for the processes that contribute to radiation carcinogenesis at the cellular/molecular levels, whole animal level, develop sound protocols for investigating the risk from internal emitters and carry out mathematical modelling work to link experimental and epidemiological approaches. Several tasks have generated large datasets from transcriptomics, proteomics and related techniques. Applications are particularly welcomed from those who have experience in bioinformatics methods of analysis to maximise the information obtained from such studies and integrate information with data from associated animal and cellular studies. We would also welcome applications that explore dose-response relationships for any cancer relevant endpoints.


Work package 6 studies the relationship between the risk of cancer at low doses and the factors rendering some individuals more sensitive to radiation-induced cancer. Our goal is to identify molecular markers that quantify individual exposure, susceptibility and/or cancer risk that can be used in low dose epidemiological studies. Applied projects aimed at performing molecular biomarker studies with existing or new epidemiological cohorts are welcomed, as are developmental projects adopting new technologies for biomarker discovery and fundamental projects aimed at determining the mechanisms that govern individual sensitivity. Integration with existing research tasks in WP5, 6 or 7 is particularly encouraged.


Work package 7
addresses the non-cancer effects resulting from exposure to low doses of ionizing radiation.
Our goal is to investigate the mechanisms behind the development of vascular effects, lens opacities, neurological defects and immunological changes. Several tasks have generated qualitative and quantitative information about molecular epidemiological approaches and standard protocols for the study of vascular effects and lens opacities, as well as measurable markers evaluating the initial response of the endothelium and the impact on neurogenesis for low and high energy radiation at different radiation doses delivered through acute versus chronic external irradiation and internal contamination. On-going tasks aim at investigating the effects of low doses on induction of anti-inflammation and aneurysm development, the contribution of low-dose X-radiation in induction of cataractogenesis and influencing genetic & cell communication factors, and the effects on brain microvascular pericytes. This call would particularly welcome future proposals allowing the determination of suitable biomarkers to be considered in epidemiological studies of radiation-induced non-cancer effects.

The selected proposal(s) will be integrated to the existing work packages.

Supporting documentation (printable versions):

  • 3rd DoReMi Competitive call announcement
  • The DoReMi-2013 Guide for Applicants [corrected version to be used added on 25 October]
  • Proposal template (extract from Guide for applicants) [corrected version to be used added on 25 October]
  • The edited version of the existing DoReMi consortium agreement (redundant information removed)
  • Transitional Research Agenda TRA
  • TRA Statement, version 3


Expected duration of participation in project:
From July 2014 to December 2015, depending on the complexity of the work.

Total Commission funding available: The proposals can be submitted by an individual organisation or a small consortium consisting of max. 2 partners. A maximum of 200 000 € is available for the Call.



Call identifier: DoReMi-2013

Language in which proposal should be submitted: English

Date and time of close of call: Wednesday, 11 December 2013; 17h00 Brussels time

Mail address for further information (Project coordinator): doremi@stuk.fi

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